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Finasteride proscar is used alone or in combination with another medication doxazosin cardura to treat benign prostatic hypertrophy bph,.
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In the human prostate, doxazosin antagonizes phenylephrine alpha1 agonist -induced contractions, in vitro , and binds with high affinity to the alpha1a adrenoceptor, which is thought to be the predominant functional type in the prostate.
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The oral ld 50 of doxazosin retard is greater than 1000 mg kg in mice and rats.
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in one fixed dose study, doxazosin therapy 4 mg to 8 mg, once daily resulted in a significant and sustained improvement in maximum urinary flow rate of 2.